Complications That Can Be Caused By Hypogonadism


Hypogonadism is a clinical syndrome which is characterized by testosterone deficiency. According to the studies, a large proportion of men aging between 40 and 79 suffer from low testosterone. Although the level of testosterone can be affected by various reasons, the primary causes of hypogonadism are as follows:

  • Testicular failure
  • Pituitary and hypothalamic failure
  • Age related dysfunction



Testosterone is made in the testes and it is an important male sex hormone that is required for various bodily functions other than for normal reproductive and sexual function. Testosterone plays a vital role in the occurrence of changes that occur during the puberty stage such as the development of penis and facial and body hair. Testosterone is also important for the overall health such as its role in the growth and health of bones and muscles and its role in controlling the mood and many more. Testosterone deficiency is associated with many health problems. Hypogonadism is of two types:

Primary hypogonadism - It is a term that is used when the testosterone deficiency results from a problem within testes. Usually, it occurs due to a genetic factor and the most common genetic cause is Klinefelter's syndrome.

Secondary hypogonadism - It is a term that is used when the testosterone deficiency results from the complex hormonal system that is responsible for producing male sex hormone.

Testosterone deficiency is associated with various health problems and some of the health problems that can result from testosterone deficiency are as follows:

Erectile dysfunction

Erectile dysfunction, also known as impotence is one of the most frequent complaints made by men these days and lack of testosterone in the body is the common cause of it. Erectile dysfunction is defined as a condition in which attaining and maintaining sufficient penile erection is a questionable aspect for a man. This sexual dysfunctioning severely impact the quality of life of the man as well as of his partner. Not attaining and maintaining erections does not necessarily indicate erectile dysfunction, but a man is said to be suffering from erectile dysfunction when he persistently fails to attain erections.

There is a strong relationship between low testosterone level and increased risk of developing erectile dysfunction. In fact, sexual functioning is said to be dependent on testosterone level. This is because testosterone has a direct effect on the release of nitric oxide, a decline in the level of testosterone leads to a reduction in the release of nitric oxide. Nitric oxide plays a vital role in the erectile function and any impairment in the release of nitric oxide leads to the occurrence of problems with erections.


Also Read: Sildenafil Can Treat Impotence  


Osteopenia is a common term that is used by doctors to indicate low bone density in an individual. The bones of the people having osteopenia are weaker than the normal and sometimes osteopenia is considered to be a warning sign as untreated osteopenia leads to the occurrence of osteoporosis. It is not necessary that patients having osteopenia will also develop osteoporosis but it increases the risk of developing it. Generally, osteopenia is painless and it is often left undiagnosed until an individual experience fracture even after a short fall. Osteopenia results from low bone mineralization and low body mass density. It is essential to maintain the health of the bones. Although symptoms do not occur in osteopenia, some of the symptoms that can occur include bone pain, muscle spasm, muscle weakness, and difficulty walking.  

Multiple studies suggest that there is a link between testosterone level and body mass density. There is evidence to show that low testosterone level together with chronic glucocorticoid or corticosteroid use is the leading cause of osteopenia in men. Studies clearly demonstrated that lowering testosterone level leads to a decrease in bone density and significantly increases the risk of developing osteopenia. Therefore there is a strong need for a normal testosterone level to sustain normal body mass density.

Diabetes mellitus

Almost all of us are aware that diabetes mellitus is a chronic condition and the prevalence of this disease is increasing rapidly throughout the world. It is associated with a wide range of complications and has become one of the leading cause of deaths. Diabetes mellitus is defined as a condition in which the blood sugar level of an individual becomes too high than normal. Although the altered sugar level of the body can be due to two mechanisms, either due to a failure of pancreas to produce enough insulin or due to the inability of the body to use produced insulin effectively, it is strongly believed that there is a correlation between low testosterone level and an increased risk of diabetes mellitus.

Studies have made it apparent that testosterone plays a significant role in glucose homeostasis. Low testosterone level is considered to be a risk factor for developing diabetes mellitus and one of the reasons for this correlation is that there is a link between insulin sensitivity and testosterone levels. Low testosterone level can affect the body’s ability to use the produced insulin.


Depression is a psychological disorder that is defined as a feeling that is more than being sad. Feeling low and sad is a normal part of life and we all feel sad at some point in life, but depression is a condition which triggers symptoms which are distressing and affect the normal daily activities. There are some pieces of evidence that suggest that low testosterone level in the body can worsen the symptoms of depression. Testosterone has a strong impact on the mood if an individual and when the level of testosterone is altered, it causes low mood.



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